Overview
Full guide to all 13 characters in The Binding of Isaac: Rebirth. Includes stats, how to unlock, character-specific unlocks, related achievements, and more. Updated for Afterbirth!
Introduction
Welcome to The Binding of Isaac: Rebirth character guide!
Please use the Guide Index list on the right to quickly navigate to the desired character’s information. Included in this guide:
- All 13 Characters
- Starting stats, items, and effects
- How to unlock every character
- Character’s item unlocks (under construction)
- Biblical Reference
Isaac
Starting Items
One regular bomb.
The D6 (once unlocked)
On Use: Any Treasure Room item will be rerolled into a different item. (Defeat enemy Isaac in the Cathedral using ??? to unlock this item.)Starting Effects
None
How to Unlock
Default Character
Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
Biblical Reference
Child whom God asked his father Abraham to sacrifice.
Magdalene
Starting Items
Yum Heart
On Use: Heals one Red Heart. Recharge: Four rooms.Starting Effects
None
How to Unlock
Have 7 or more Red Heart containers at one time.Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
Biblical Reference
Mary Magdalene, a prostitue before meeting and befriending Jesus.
Cain
Starting Items
One regular key.
Starting Effects
Lucky Foot
Passive: Increases LuckHow to Unlock
Have 55 or more pennies at once.Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
Biblical Reference
Son of Adam and Eve. Commited the first act of murder when he killed his brother Abel.
Judas
Starting Items
Three pennies.
Book of Belial
On Use: Increases damage dealt for the current room. Recharge: Three rooms
Starting Effects
None
How to Unlock
Defeat Satan.Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
Biblical Reference
One of the 12 disciples. Betrayed Jesus in exchange for money.
Eve
Starting Items
None
Starting Effects
Dead Bird
Passive: When hit, a dead bird spawns and attacks enemies in the current room.W’♥♥♥♥ of Babylon
Passive: When at one heart of life, damage and speed is increased.How to Unlock
Do not pick up any Hearts (Red, Spirit, Eternal, Demon) for two floors.Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
Biblical Reference
First woman. Took a bite from the forbidden fruit, comitting the first act of sin.
Samson
Starting Items
None
Starting Effects
Bloody Lust
Passive: Each time damage is taken, damage dealt is increased a small amount. Damage bonus resets each floor.How to Unlock
Do not take damage for two floors.Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
Biblical Reference
Born by God to defeat the Philistines. After revealing his secret, lost his power and was subsequently captured and blinded.
Azazel
Starting Items
0 – The Fool
On Use: Teleports user to starting room on current floor.Starting Effects
Special
Special
Flying
How to Unlock
Make three deals with the Devil in one run.Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
Biblical Reference
A scapegoat, or in some translations, the name of a fallen angel who helped further the corruption of Man preceeding the great flood.
Lazarus
Starting Items
A random pill.
Starting Effects
Special
Anemic (after revive)
Passive:Range up. Passive: When damage is taken, leave a trail of blood that damages enemies. Resets when leaving current room.How to Unlock
Have four Spirit Hearts at once.Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
Biblical Reference
Was ressurected by Jesus four days after dying.
Eden
Eden is neither male nor female.
Using Eden requires the use of a special token. Additional tokens are obtained each time Mom’s Heart / It Lives is defeated.
Starting Items
Randomized, see below
Starting Effects
Special
- Randomized Stats
- Random hair style
- 1: coin, bomb, key, pill, or card
- 0-1: activated item
- 0-2: passive items
How to Unlock
Defeat The Womb chapter.Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
Biblical Reference
None directly, although it’s interesting to note that the place Adam and Eve orignally resided was the Garden of Eden.
???
Also known as the Blue Baby.
Starting Items
The Poop
On Use: Spawns a poop. Recharge: One room.Starting Effects
Special
How to Unlock
Defeat Mom’s Heart ten times.Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
Biblical Reference
None. Often thought to refer to Edmund McMillen, original game creator, and some of his past work which depict a similar character.
The Lost
Dies if game is left mid-run.
Starting Items
One penny.
Starting Effects
Flying
Special
How to Unlock
You must die as specific characters and by specific means. These four can be done in any order (in one play session) as long as there are NO other losses in between. Currently, seeds will work. The following order is recommended:
- As Isaac, die by a Mulliboom’s explosion in either the Basement or Cellar (Seed: JTMD EZPF, go down).
- As Magdalene, die by your own bomb in either the Caves or Catacombs.
- As Judas, die by Mom. Easiest way is to damage self to half a heart before entering then running to middle of room.
- As Azazel, die by Satan during his second phase (after The Fallen, before the hooves) in Sheol.
Mulliboom:
Appears rarely. Slightly more common in Cellar. Setting difficulty to Hard adds a few more rooms with Mullibooms to the generation list, making them a bit more common to encounter. You can use your own bombs to blow up doors to get through rooms with lots of enemies without killing them, saving some time. Unlike other explosions, these deal only a half heart of damage.Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
Biblical Reference
None directly. A lost soul, resembles the spirit that leaves the body of other characters upon death.
Lilith
Starting Items
Box of Friends
On Use: Duplicate’s Isaac’s familiars for the duration of the current room. Recharge: Two roomsStarting Effects
Special
Incubus
Passive: Summons a familiar that fires tears. Gains the same effects as Isaac’s tears.Special
How to Unlock
Beat Greed Mode with AzazelRelated Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
Biblical Reference
In some texts, Lilith was Adam’s first wife but was cast out of the Garden of Eden when she refused to listen to God, who later replaced her with Eve. Lilith is often referenced with demonic associations in bibical texts.
Keeper
Starting Items
One regular bomb.
One coin (after defeating the Hush with Keeper).
Wooden Nickel
On Use: 50% chance to drop a coin. Recharge: One room (Unlocked by defeating Isaac in the Cathedral) Store Key
Trinket: May open shops without using a key. (Unlocked by defeating Satan in Sheol) Starting Effects
Special
Special
Special
How to Unlock
Related Achievements
These achievements are gained when you complete an area with this character, unlocking an item.
Biblical Reference
n/a
Conclusion
You’ve reached the end of this guide, I hope it answered your questions!
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