Overview
This guide will show you everything about the boss rush
The Boss Rush
The Boss Rush is an optional Room that becomes available by beating Mom in less than 20 minutes.
In the center of a large room there will be 4 random Items to choose from. Picking up an item will cause the other three to disappear and start the 15 wave Boss Rush. The next wave will only begin after both bosses have been killed. Completing the Boss Rush will also reward 1 more Item, separate from the 4 seen when first entering the room.
Waves
The Boss Rush contains 15 waves, each wave will have two bosses, and those bosses will be champion.
Blighted Ovum[bindingofisaacrebirth.gamepedia.com]
Gurdy Jr.[bindingofisaacrebirth.gamepedia.com]
The Carrion Queen[bindingofisaacrebirth.gamepedia.com]
The Wretched[bindingofisaacrebirth.gamepedia.com]
Peep[bindingofisaacrebirth.gamepedia.com]
The Duke of Flies[bindingofisaacrebirth.gamepedia.com]
Blastocyst[bindingofisaacrebirth.gamepedia.com]
Loki[bindingofisaacrebirth.gamepedia.com]
Gemini[bindingofisaacrebirth.gamepedia.com]
Steven[bindingofisaacrebirth.gamepedia.com]
3Larry Jr.[bindingofisaacrebirth.gamepedia.com]
Fistula[bindingofisaacrebirth.gamepedia.com]
C.H.A.D[bindingofisaacrebirth.gamepedia.com]
Monstro[bindingofisaacrebirth.gamepedia.com]
Gurdy[bindingofisaacrebirth.gamepedia.com]
Chub[bindingofisaacrebirth.gamepedia.com]
Gish[bindingofisaacrebirth.gamepedia.com]
Monstro II[bindingofisaacrebirth.gamepedia.com]
Pin[bindingofisaacrebirth.gamepedia.com]
Widow[bindingofisaacrebirth.gamepedia.com]
3 The Hollow[bindingofisaacrebirth.gamepedia.com]
The Husk[bindingofisaacrebirth.gamepedia.com]
The Bloat[bindingofisaacrebirth.gamepedia.com]
Mask of Infamy[bindingofisaacrebirth.gamepedia.com]
Pestilence[bindingofisaacrebirth.gamepedia.com]
Famine[bindingofisaacrebirth.gamepedia.com]
Death[bindingofisaacrebirth.gamepedia.com]
War[bindingofisaacrebirth.gamepedia.com]
The Fallen[bindingofisaacrebirth.gamepedia.com]
The Headless Horseman[bindingofisaacrebirth.gamepedia.com]
Unlockables
Isaac’s Head – Beat the Boss Rush with Isaac
Cain’s Other Eye – Beat the Boss Rush with Cain
Maggy’s Bow – Beat the Boss Rush with Magdalene
Judas’ Shadow – Beat the Boss Rush with Judas
???’s Only Friend – Beat the Boss Rush with ???
Eve’s Mascara – Beat the Boss Rush with Eve
Samson’s Chains – Beat the Boss Rush with Samson
Missing No. – Beat the Boss Rush with Lazarus
Undefined – Beat the Boss Rush with Eden
The Nail – Beat the Boss Rush with Azazel
D100 – Beat the Boss Rush with Spoiler
Tips
- The player’s playtime can be checked at any moment by pressing TAB.
- Each boss will drop red hearts on normal difficulty. Dark Bum can turn these into Soul Hearts, providing loads of extra health.
- Take out The Carrion Queen quickly, as its Red Poops will remain for the rest of the Boss Rush. They can be advantageous though, as other bosses can also take damage from these Poops. In particular, bouncing bosses like The Hollow and The Husk can quickly kill themselves on contact.
- Wave 9 can be quite difficult as Monstro II can catch the player off guard with an offscreen blood laser. The black creep left by Gish will also remain until the end of the wave (regardless of if Gish is killed first).
- In wave 14 first try to kill Death, because he shoots Sickles
- In wave 12 : Bloat should be taken out first because if it’s ability jump near you shooting tears (or whatever projectile he shots) Thanks to Hellcat
post other tips which I will add here
Other Things
The information I got on the wiki.
and another thing is that when you finish a boss rush another item will appear and you can get it(unconfirmed)
And sorry about my english