Overview
This guide will teach you how to unlock all of the characters and the easiest way to do so!
Introduction
This is my first guide ever so feedback is greatly appreciated!
I do not have all the images/names of items yet so if you know what they are please comment!
Thanks and enjoy 😀
Isaac
Isaac is the basic and 1st character you unlock.
Magdeline
She is the 2nd character on the wheel.
To unlock her you must have Seven heart containers at one point.
Cain
Cain is the 3rd character on the wheel and it doesn’t require that much skill to get him.
He is one of the best characters because he spawns with a key and a lucky foot.
Tips:
•DO open shops to have that chance to kill greed, DON’T buy items in the shop
•DO open secret rooms to have the chance of coins and killing greed, DON’T get hit by greed
•DON’T open arcades, it costs a penny to open an arcade and although you may gain other items, you probably won’t profit on your pennies
To unlock cain, you need 55 Pennies at one point. The reason I say coins is because dimes, nickles, and pennies all add up.
Eve
Eve is the 5th character on the wheel.
To unlock her you must go through two floors without picking up any hearts.
Tip:
•DO try to unlock before fighting mom, DON’T try to do this in the womb because you want max health when fighting Mom/Mom’s Heart
•DO try to gets lots of heart containers/HP buffs, DON’T pick up hearts/soul hearts/black hearts/spirit hearts. (I am 70% sure all of those count towards the challenge)
EDIT: Picking up black hearts does not effect the challenge of unlocking eve – Silver Wolfe
Lazarus
Lazarus is the ___ hero on the wheel. He starts with the same stats as Isaac but with an extra LIFE not heart container. When killed he will spawn with his base heart containers but with this time an item called ‘Anemic’ which leaves a trail of blood (creep) that damages enemies that walk into it. Once you get injured in a room, it will start to leave blood and reset the next.
To unlock him, you need to have three or more soul hearts at one time.
Starts with: Same stats as Isaac but with an extra life
Respawns with: Base heart containers and the item anemic
Tips: “Easiest way I’ve found is to pick up either Dark Bum or Guppy’s Paw with more than two heart containers. Just don’t get hit and you’ll get it eventually.” -(Under Contributors)
The Lost
The lost is the “secret” character in Rebirth.
Items: He starts with flying and no hearts (you cannot increase health from HP items or soul/black/eternal hearts).
YOU MUST DO ALL OF THESE IN THIS EXACT ORDER. If you die or win some other way, you must completely restart. Holding R as a character can work for him though.
How to unlock:
1) Die to a mulliboom as Isaac
2) Kill yourself with a bomb as Magdalene
3) Die to mom’s foot as Judas
4) Die to stage 2 of Satan as Azazel
To be (not) continued…
I have unlocked every character in both Rebirth and Afterbirth
It is highly unlikely I will update this guide fully again.