Overview
This is a guide telling you about all the challenges, how they’re unlocked and what item it unlocks!This guide will SOON feature a video walkthrough for each and every challenge. Keep your eyes peeled!Also, if you find that this guide has helped you, please click on the thumbs up button and maybe add it to your favourites? Cheers!
All the challenges!
Challenge
Conditions
Goal
Unlocked by
Unlocks
Pitch Black
You cannot see your health and rooms are darker.
Treasure rooms available. No shops.
Treasure rooms available. No shops.
Kill Mom!
Default
Rune of Hagalaz.
High Brow
Start with; Number One, E. Coli, Butt Bombs, Flush as your space-bar item and Petrified Poop as your trinket.
No treasure rooms. Shops available.
No treasure rooms. Shops available.
Kill Mom!
Default
Rune of Jera.
Head Trauma
Start with; Tiny Planet, Soy Milk, Small Rock and Iron Bar.
No treasure rooms. Shops available.
No treasure rooms. Shops available.
Kill Mom!
Default
Rune of Ehwaz
Darkness Falls
Start with; Pentagram, Dead Bird, ♥♥♥♥♥ of Babylon, Razor Blade, Sacrificial Dagger and Dark Matter.
No treasure rooms. Shops available.
No treasure rooms. Shops available.
Kill Satan
It Lives and Eve.
Rune of Dagaz.
The Tank
Start with; Bucket of Lard, Infamy, Yum Heart and Thunder Thighs.
No treasure rooms. Shops available.
No treasure rooms. Shops available.
Kill Mom!
Unlocking Magdalene
Rune of Ansuz.
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Solar System
Start with; Transcendance, Distant Admiration, Forever Alone and Halo of Flies. Cannot shoot tears during this run.
No treasure rooms. Shops available.
No treasure rooms. Shops available.
Kill Mom’s Heart
Unlocked Transcendance.
Rune of Perthro
Suicide King
Start with; Ipecac, My Reflection and Mr. Mega.
No treasure rooms. Shops available.
No treasure rooms. Shops available.
Kill Isaac
Unlocking ‘It Lives’
Suicide King
Cat Got Your Tongue
Start with; Guppy’s Tail, Guppy’s Head and Guppy’s Hairball. Cannot shoot tears during this run.
No treasure rooms. Shops available.
No treasure rooms. Shops available.
Kill Mom!
Transforming into Guppy.
Rune of Algiz
Demo Man.
Start with; Dr. Fetus, Remote Detonator and Matchstick as your Trinket.
No treasure rooms. Shops available.
No treasure rooms. Shops available.
Kill Mom’s Heart.
Unlocking Dr. Fetus
The Chaos Card
Cursed!
Start as Magdalene with; Yum Heart, Raw Liver, The Compass, Treasure Map, Blue Map and Child’s Heart as your Trinket. Leaving rooms will damage you, like leaving/entering a Curse Room.
No treasure rooms. Shops available.
No treasure rooms. Shops available.
Kill Mom!
Unlocking Madgalene
Credit Card
Glass Cannon
Start as Judas with; Epic Fetus and Loki’s Horns.
No Treasure rooms or Shops.
No Treasure rooms or Shops.
Kill Satan
Unlock Epic Fetus (Challenge #19) and Loki’s Horns
Rules Card
When Life Gives You Lemons
Start with; Lemon Mishap, 9-Volt, Habit and 1 Lemon Party Pill.
No Treasure rooms. Shops available
No Treasure rooms. Shops available
Kill Mom!
Default
A Card Against Humanity
Beans!
Start with; Pyro, The Bean, The Black Bean, 9-Volt and Butt Bombs. Cannot use tears. No treasure rooms. Shops available
Kill Mom!
Default
Burnt Penny
It’s in the Cards
Start with; Deck of Cards, Starter Deck, The Battery, 9-Volt and 2 random tarot cards.No treasure rooms. Shops available
Kill Mom!
Default
SMB Super Fan
Slow Roll
Start with; Polyphemus, My Reflection and Cupid’s Arrow.
No treasure rooms. Shops available
No treasure rooms. Shops available
Kill Mom!
Default
Swallowed Penny
Computer Savvy
Start with; Technology, Technology 2 and Spoon Bender.
No treasure rooms. Shops available
No treasure rooms. Shops available
Kill Mom!
Default
Robo-Baby 2.0
Waka Waka
Start with; Strange Attractor and Anti-Gravity.
No treasure rooms. Shops available
No treasure rooms. Shops available
Kill Mom!
Default
Death’s Touch
The Host
Start with; Spider Baby, The Mulligan and The Tick.
No treasure rooms. Shops available
No treasure rooms. Shops available
Kill Mom!
Default
Technology .5
The Family Man
Start with; Brother Bobby, Sister Maggy, Dad’s Key, BFFS! and Rotten Baby. Cannot use tears, only familiars.
No treasure rooms. Shops available
No treasure rooms. Shops available
Kill Isaac
Unlocking ‘Dad’s Key’ and ‘It Lives’
Epic Fetus
The Purist
No item rooms or starting items.
No treasure rooms. Shops available
No treasure rooms. Shops available
Kill Mom’s Heart.
Killing Mom’s Heart for the first time.
Rune of Berkano
Updates.
Update 1.0
-Guide released!
Update 1.1
– Added if Treasure rooms/Shops are available/unavailable.
– Changed the image of the guide. The other one was a kinda strain on my eyes.