Overview
This will basically be the AFTERBIRTH guide to ‘Q’ activated items
Cards
0 – The Fool: Teleports you to the starting room on the current floor
I – The Magician: Single room homing shots
II – The High Priestess: ‘Moms’ Leg is summoned to stomp on the enemy with the highest health (300 Dmg) If no enemies are around, Isaac is hit instead
III – The Empress: Triggers ‘Babylon’ for a single room
IV – The Emperor: Teleports you to the boss room of the floor
V – The Heirophant: Spawns two soul (blue/temporary) Hearts
VI – The Lovers: Drops two red hearts (unless used in a super secret room containing a black or eternal heart, They will be dropped instead)
VII – The Chariot: Activates the ‘My Little Unicorn’ effect (see ‘My Little Unicorn)
VIII – Justice: Spawns a key, coin, bomb and heart
IX – The Hermit: Teleports you to the store, If there is no store it will act as a ‘telepills’ instead
X – Wheel Of Fortune: Spawns either a slot machine or fortune teller
XI – Strength: All stat increase (Except Tears stat) and adds a temporary full heart container for that room
XII – The Hanged Man: Removes isaacs head from his body, Giving him temporary flight for a single room
XIII – Death: Deals 40 damage to all enemies in the room
XIV – Temperance: Spawns a Blood Donor machine
XV – The Devil: Increases your damage stat by 2 for a single room
XVI – The Tower: Spawns 6 active bombs randomly around the room
XVII – The Stars: Teleports you to the Treasure room, If None is avaliable (challenge run or from the womb downwards) it acts as a ‘Telepills’
XVIII – The Moon: Teleports you to a secret room
XIX – The Sun: Restores all health, Deals 100 damage to all enemies and reveals the map (but not the super secret room)
XX – Judgement: Spawns a Beggar
XXI – The World: Reveals the entire floor (But not the super secret room) Is not effective if under the ‘Curse of the lost’ or the effect of ‘Amnesia’
2 of Clubs: Doubles your bombs (If you have 0, you get 2)
2 of Spades: Doubles you keys (If you have 0, you get 2)
2 of Diamonds: Doubles your coins (If you have 0, you get 2)
2 of Hearts: Dobles your current hearts and uses said hearts to fill empty heart containers (Does not add them. Does not affect Soul, Sin or eternity hearts)
Joker: Teleports you to a Devil or Angel room
Suicide King: Kills the player and spawns items and/or chests around them. Do not use if you have no extra lives.
Chaos Card: Throwable item, Kills anything it hits, Opens closed normal doors.
Credit Card: Converts all exchange items (devil room, shop) into free items, Use in the room.
Rules Card: Hint giver, Use to get hints on rooms, bosses e.t.c.
A Card Against Humanity: Fills the room with poop…
? Card: Copies the spacebar/Chargable items effect (Does not use the spacebar items charge)
Get Out Of Jail Free: Opens all doors in the room, Even special ones (Mega satan door)
Runes
Hagalaz: Destroys all breakable objects in the room
Jera: Clones all item pickups, chests and items in the room (cannot clone Jera)
Ehwaz: Spawns a trapdoor to the next floor (1/12 to spawn a crawlspace instead)
Dagaz: Removes the floors curse, Adds a soul heart
Ansuz: Reveals the whole map
Perthro: One use D6 (Rerolls the Item pickup into a different one)
Berkano: Summons 3 blue flies and 3 blue spiders
Algiz: Grants a 60 second shield
Blank Rune: Random rune effect, 1/4 chance to spawn another Blank Rune
Pills
48 Hour Energy: Spawns 2 batteries
Amnesia: Replaces the map with a ? sign for a whole floor
Bad Gas: You fart, Poisoning nearby enemies
Bad Trip: Does 1 Hearts damage to you, If used while at 1 Heart left it will fully heal you
Balls Of Steel: Gives you 2 Soul Hearts
Bombs Are Key: Swaps the amount of bomb and key consumables you hold with each other
Explosive Diarrhea: Spawns 5 active bombs behind issac, 1 per second
Full Health: Self explanatory
Health Down: Down 1 Health Container (However it becomes a ‘Health Up’ Pill when the player has only one Heart Container)
Health Up: Up 1 Health container
Hematemesis: Empties all but one red heart container and spawns 1-4 full red heart pickups. If you only have half of a heart left, it will heal you to one heart. If used without any red heart containers, no health will be deducted, but red hearts will still spawn. If used in a Black Heart or Eternal Heart-containing Super Secret Room, it will spawn those types of hearts instead
I Can See Forever: Opens all Secret rooms
I Found Pills: Changes the appearance of your face. This pill is cosmetic only, and the effect disappears when you leave the room
Lemon Party: Spawns a large yellow pool (similar to ‘Lemon Mishap’) around you. Greatly damages any enemy that steps on it
Luck Down: Down 1 Luck
Luck Up: Up 1 Luck
Paralysis: Prevents you from moving for a short duration
Pheromones: Charms all enemies in the room for a short period of time
Puberty: Causes you to grow four hairs from the top of your head and zits on your face. This pill is cosmetic only, and will stay for the rest of the run
Pretty Fly: Grants 1 fly orbital that circles you, blocking projectiles and damaging fly-type enemies on touch
Range Down: Decreases range by 2
Range Up: Increases range by 2.5
R U a Wizard?: Tears are shot diagonally outwards for about one minute. This effect does not reset upon exiting the room
Speed Down: Decreases your movement speed by 0.12
Speed Up: Increases your movement speed by 0.15
Tears Down: Decreases your tears by 0.28
Tears Up: Increases your tears by 0.35
Telepills: You get teleported to a random room. Has a small chance to teleport you to the I AM ERROR room, and an extremely small chance to teleport you to the Black Market, like Undefined
Addicted: Makes you take a full heart of damage from all sources for the current room. Unlocked by completing Challenge #24: PAY TO PLAY
Friends Till The End!: Spawns three Blue Flies
Infested!: Destroys all poop in the room and spawns a single Blue Spider under you and on each destroyed poop
Infested?: Spawns Blue Spiders equal to the number of enemies in the room. If there are no enemies in the room, spawns 1-3 Blue Spiders
One Makes You Smaller: Decreases your size and increases the pitch of your voice. This effect decreases the size of your hitbox
One Makes You Larger: Increases your size and decreases the pitch of your voice. This effect does not increase the size of your hitbox
Percs: Gives The Wafer effect while in the room. Unlocked by completing Challenge #24: PAY TO PLAY
Power Pill: Activates an effect similar to ‘The Gamekid’
Re-Lax: For a short time, poop spawns wherever you move, like Explosive Diarrhea but with poop. A higher move speed means you can touch more tiles in the same time. A pun on laxatives. Unlocked by completing Challenge #25: Have A Heart
Retro Vision: Briefly pixelates the screen 3 times over 30 seconds
???: Gives the Curse of the Maze effect for the remainder of the floor. The effect can stack with other curses. If no other curses are active for the floor, Curse of the Maze will appear under the level name when TAB is held. This effect cannot be negated by Black Candle. Unlocked by completing Challenge #25: Have A Heart
Other ‘Q’ Items
Emergency Contact: Spawns two ‘Mom’ hands to grab two enemies
Dice Shard: Uses the D6 and D20 effects at the same time