Guide how to unlock ALL 641 achievements

Translation

The author of this guide does not speak English. However, I did my best to translate everything using a translator and Wiki. I would be very grateful for any help with writing or for support in the form of Steam points. Thank you!

↓ Original ↓
https://steamcommunity.com/sharedfiles/filedetails/?id=3408959992

Introduction

In this guide, you can find ways to achieve something new in the game and unlock it.

If you find a way to have suggestions for improvement, the comments are open.

Characters

Isaac

unlocked by default

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Magdalene

Have 7 or more Red Heart
containers at one time.

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Cain

Hold 55 Coins at one time

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Judas

Defeat Satan

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

???

Defeat Mom's Heart 10 times

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Eve

Don't pick up any Hearts for 2 floors in a row

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Characters

Samson

Complete 2 floors in a row without taking damage

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Lazarus

Have 4 or more Soul Hearts at one time

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Azazel

Make 3 Deals with the Devil in one run

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Eden

Complete Chapter 4

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

The Lost

Die in a Sacrifice Room while holding Missing Poster

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Lilith

Defeat Ultra Greed as Azazel

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Characters

Keeper

Donate 1000 Coins to the Greed Donation Machine

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Apollyon

Defeat Mega Satan

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

The Forgotten

Dig a grave with mom's shovel at the level of the dark room
"More details"[bindingofisaacrebirth.fandom.com]

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Bethany

Defeat Mom's Heart/It Lives! on
hard mode as Lazarus, without dying at all

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Jacob and Esau

Defeat Mother

Unlock

Target

Boss Rush

Mom's Heart

Satan

Isaac

???

The Lamb

Ultra Greed

Ultra Greedier

Hush

Mega Satan

Delirium

Mother

The Beast

Completion Marks

Tainted Characters

Tainted Isaac

Use Red Key (etc.) to open the hidden closet in Home as Isaac

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Tainted Magdalene

Use Red Key (etc.) to open the hidden closet in Home as Magdalene

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Tainted Cain

Use Red Key (etc.) to open the hidden closet in Home as Cain

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Tainted Judas

Use Red Key (etc.) to open the hidden closet in Home as Judas

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Tainted ???

Use Red Key (etc.) to open the hidden closet in Home as ???

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Tainted Eve

Use Red Key (etc.) to open the hidden closet in Home as Eve

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Tainted Samson

Use Red Key (etc.) to open the hidden closet in Home as Samson

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Tainted Lazarus

Use Red Key (etc.) to open the hidden closet in Home as Lazarus

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Tainted Azazel

Use Red Key (etc.) to open the hidden closet in Home as Azazel

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Tainted Characters

Tainted Eden

Use Red Key (etc.) to open the hidden closet in Home as Eden

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Tainted Lost

Use Red Key (etc.) to open the hidden closet in Home as The Lost

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Tainted Lilith

Use Red Key (etc.) to open the hidden closet in Home as Lilith

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Tainted Keeper

Use Red Key (etc.) to open the hidden closet in Home as Keeper

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Tainted Apollyon

Use Red Key (etc.) to open the hidden closet in Home as Apollyon

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Tainted Forgotten

Use Red Key (etc.) to open the hidden closet in Home as The Forgotten

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Tainted Bethany

Use Red Key (etc.) to open the hidden closet in Home as Bethany

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Tainted Jacob

Use Red Key (etc.) to open the hidden closet in Home as Jacob and Esau

Isaac, ???, Satan, The Lamb

Ultra Greedier

Hush and Boss Rush

Mega Satan

Delirium

Mother

The Beast

Normal characters have 14 unlocks
Tainted characters have 7

392

Challenges

Unlock

№

Name

1

Pitch Black

2

High Brow

3

Head Trauma

4

Darkness Falls

___

Defeat Mom's Heart 11 times and defeat ??? as Eve

5

The Tank

_______________

Have 7 or more Red Heart Containers at one time

6

Solar System

_______________

Defeat Mom's Heart 3 times

7

Suicide King

___

Defeat Mom's Heart 11 times and unlock Lazarus

8

Cat Got Your Tongueл

_______________

Become Guppy

9

Demo Man

___

Defeat Mom's Heart 9 times

10

Cursed!

_______________

Have 7 or more Red Heart Containers at one time

11

Glass Cannon

___

Beat The Family Man (challenge #19), defeat Lokii, and unlock Judas

12

When Life Gives You Lemons

13

Beans!

14

It's in the Cards

15

Slow Roll

16

Computer Savvy

17

Waka Waka

18

The Host

19

The Family Man

___

Pick up both Key Pieces from the Angels in one run

20

Purist

_______________

Defeat Mom

21

XXXXXXXXL

_______________

Defeat Mom

22

SPEED!

_______________

Defeat Mom

23

Blue Bomber

___

Destroy 10 Tinted Rocks and defeat Mom's Heart 11 times

24

PAY TO PLAY

___

Defeat Isaac as Cain and destroy 10 Tinted Rocks

25

Have a Heart

_______________

Defeat Mom

26

I RULE!

___

Defeat Mega Satan and unlock The Negative

27

BRAINS!

_______________

Defeat Isaac 5 times

28

PRIDE DAY!

_______________

Defeat Mom

29

Onan's Streak

___

Unlock Judas and It Lives.

30

The Guardian

_______________

Defeat Mom

31

Backasswards

___

Defeat Mega Satan and unlock The Negative

32

Aprils Fool

_______________

Defeat Mom

33

Pokey Mans

___

Defeat Mom's Heart 11 times

34

Ultra Hard

___

Defeat Mega Satan and unlock The Negative

35

Pong

_______________

Defeat Isaac 5 times

36

Scat Man

37

Bloody Mary

___

Unlock Bethany, Blood Bag, and It Lives!

38

Baptism by Fire

___

Defeat Satan as Bethany, defeat Mom's Heart
11 times, and unlock Maggy's Faith

39

Isaac's Awakening

_______________

Defeat Mother

40

Seeing Double

_______________

Defeat Mother

Challenges

41

Pica Run

___

Defeat Mom's Heart 11 times and unlock Marbles

42

Hot Potato

_____________

Unlock Tainted Forgotten

43

Cantripped!

_____________

Unlock Tainted Cain

44

Red Redemption

_____________

Unlock Tainted Jacob

45

DELETE THIS

_____________

Unlock Tainted Eden

45 for completion
34 for open

79

Donations

Donation Machine

Unlock

Coins

10

20

lvl

50

100

lvl

150

200

lvl

400

600

lvl

900

999

Greed Donation Machine

Unlock

Coins

2

14

33

68

111

234

439

500

666

879

999

1000

Donation Machine - 10
Greed Donation Machine - 11

21

Final Bosses

Mom

First murder

Kill using the Bible

Mom's Heart

Defeat Mom's Heart 1 times.

Defeat Mom's Heart 2 times.

Defeat Mom's Heart 3 times.

Defeat Mom's Heart 4 times.

Defeat Mom's Heart 5 times.

Defeat Mom's Heart 6 times.

Defeat Mom's Heart 7 times.

Defeat Mom's Heart 8 times.

Defeat Mom's Heart 9 times.

Defeat Mom's Heart 10 times.

Defeat Mom's Heart 11 times.

Kill using the Bible

It Lives

Open Judas and It Lives

Defeat It Lives! 16 times

Defeat It Lives! 21 times

Defeat It Lives! 30 times

Kill using the Bibl

Satan

Defeat Satan

Defeat Satan 5 times

Defeat Mega Satan and unlock The Negative

Isaac

Defeat Isaac 5 times

Defeat Isaac 10 times

Defeat Isaac as Cain and destroy 10 Tinted Rocks

???

Defeat ??? and The Lamb

Defeat ??? as 3 different Characters

Defeat ??? as 6 different Characters

Complete Chapter 6

The Lamb

Defeat ??? and The Lamb

Defeat The Lamb

Defeat The Lamb in under 20 minutes

Defeat The Lamb without taking Hearts, Coins, or Bombs through the entire run

Complete a Victory Lap by defeating The Lamb

Complete Chapter 6

Mega Satan

Defeat Mega Satan

Kill Mega Satan with all normal characters

Defeat Mega Satan and unlock The Negative

Hush

Defeat Hush

Defeat Hush 3 times.

Mother

Defeat Mother

Delirium

Defeat Delirium

Chapters

Chapter 1

Basement, Cellar,

Beat Chapter 1

Beat Basement 40 times

Beat all Basement bosses

Beat Chapter 1 without taking damage

Defeat Mom's Heart 11 times

Alternative

Downpour, Dross

Defeat Hush 3 times

Defeat all bosses in Downpour

Chapter 2

Caves, Catacombs, Flooded Caves

Beat Chapter 2

Beat Chapter 2 30 times

Beat all Caves bosses

Beat Chapter 2 without taking damage

Defeat It Lives! 16 times

Alternative

Mines, Ashpit

Defeat all bosses in Mines

Chapter 3

Depths, Necropolis, Dank Depths

Beat Chapter 3 20 times

Beat all Depths bossesн

Beat Chapter 3 without taking damage

Defeat It Lives! 21 times

Alternative

Mausoleum, Gehenna

Defeat all bosses in Mausoleum

Chapter 4

Womb, Utero, Scarred Womb

Defeat Mom

Beat Chapter 4 without taking damage

Defeat It Lives! 30 times

Alternative

Corpse

Enter Corpse for the first time

Chapter 6

Chest, Dark Room

Defeat Isaac 5 times

Defeat Satan 5 times

Dig up the Earth Mound in the Dark Room
more details[bindingofisaacrebirth.fandom.com]

Bosses

Defeat a Harbinger

Defeat Lokii

Defeat all 7 Deadly Sins

Defeat Gish

Defeat Steven

Defeat C.H.A.D.

Defeat Krampus

Defeat Little Horn 20 times

Defeat all 5 Harbingers

Defeat an Angel 10 times

Defeat Baby Plum 10 times

Allow Baby Plum to escape
instead of defeating her

After breaking Hornfel's minecart,
kill him before he can escape

Other

Collect 4 Band-Aid Balls in one run

Collect 4 Meat Cubes in one run

Collect 2 documents for one run:

Turn into Yes Mother?

Turn into Guppy

Turn into Beelzebub

Collect the First and Second Parts of the Key

Collect 2 documents for one run:

Use Blank Card while holding XIX - The Sun

Get a 3-win streak

Get a 3-win streak, using a different character each time

Collect every entry in the Bestiary

Restart the game 7 times by pressing the restart button

[R]

Defeat The Lamb in under 20 minutes

Defeat The Lamb without taking Hearts, Coins
or Bombs through the entire run

Complete a Chapter (floors I and II) after Basement,
start-to-finish, with only half a Heart tota

Obtain 50 items in a run

Add both the Broken Watch and the Stop Watch to your collection

Use Pandora's Box in Dark Room

Collect 2 artifacts/trinkets in one run:

Collect 2 technologies in one run:

Enter 6 Shops in one run

Add to collection:

Have Isaac die to his own explosion from Ipecac,
Bob's Rotten Head, or a Horf! pill

Use 5 Gulp! pills in one run

Spawn three charmed enemies in the same room

Have 20 Blue Flies at the same time

Get two homing effects at once

Collect three artifacts related to the stars:

Blow up The Siren's skull after defeating her

Open Mom's Chest in Home

In a single run, obtain 99 Coins, then spend all of them

Spend 40+ coins in a single Shop

Statistics

Destroy 10 Tinted Rocks

Destroy 100 Tinted Rocks

Destroy 100 rocks

Destroy 500 rocks

Destroy 100 Poops

Destroy 5 rainbow poops

Visit 10 Arcades

Die 100 times

Use XIII - Death 4 times

Blow up 20 Shopkeepers

Play either Shell Game or Hell Game 100 times

Take 10 Angel Room items

Take 25 Angel Room items

Take 20 items from Devil Rooms

Take 25 Deals with the Devil

Take 50 Deals with the Devil

Use the Blood Donation Machine 30 times

Blow up 30 Slot Machine

Defeat 20 Portals

Pick up 5 familiars in a single run

Recharge using Lil' Batteries 20 times

Sleep in a bed

Sleep in 10 beds

Increase in size 5 times in a single run

Use Cards and Runes 20 times

Purchase anything from Shops, Devil Rooms,
and/or Black Markets 50 times

Open 20 Locked Chests

Blow up doors and Secret Room walls 50 times

Acquire Blood Clot 10 times

Collect 10 "Tears Up" items or pills in one run

Acquire Rubber Cement 5 times

Donate to Battery Bums until they pay out
with an item 5 times

Kill 10 Battery Bums

Victory Lap

Complete a Victory Lap by defeating The Lamb

Complete 2 Victory Laps by defeating The Lamb

Complete 3 Victory Laps by defeating The Lamb

Daily Challenges

Get a 5-win streak in the Daily Challenges
(they don't have to be consecutive days,
only the runs you play are counted)

Complete 7 Daily Challenges
(by touching the trophy at the end)

Participate in 31 Daily Challenges
(they don't have to be consecutive; it will still
count if Isaac dies in the first room)

File progress

Golden God!

Defeat ??? and The Lamb

!Platinum God!

Collect all non-DLC items in the game,
and unlock all of the secrets and endings
(minus The Lost and his 6 unlockable items)

The Real Platinum God

Collect every non-DLC item, and unlock every
secret and ending

1001%

Unlock any 276 achievements

1000000%

Unlock any 403 achievements

Dead God

Unlock all the other achievements and collect
every item in the game

Co-op (Repentance +)

Playing an Online Match

Winning an Online Match

Winning an online Daily Run

Defeat Mom

Author of the message: LudoAlvera

SIDE NOTE: Rep+ achievments are bugged - even if you do win an online match, it will not pop up for you at first. What you have to do is go to the main screen of the game > stats > secrets > press left (it will show you the "won an online match" secret)

Doing that will automatically grant you the Win and Play an Online Match achievment on Steam!