How to unlock all characters

After certain character sections or unlocks for said characters, there may be a

• A
  
• A+
  
• R

A is Afterbirth, A+ is afterbirth plus. R is Repentance, no symbol means this is a base game character/unlock.

How to Unlock:
Starting character

Unlocks:
D6 - Kill Isaac as ???

How to Unlock:
Have 7 heart containers on a run as any character EXCEPT ???

Unlocks:
Yum Heart - Starts with it
1 Speed up pill - complete April Fools A+
1 Full Heath Pill - Complete April Fools R

How to Unlock:
Have 55+ coins in one run

Unlocks:
Lucky Foot - Starts with it.
Papeclip - give 68 coins to the Greed Donation Machine after killing Ultra Greed A

How to Unlock:
Kill Satan for the first time.

Unlocks:
Book of Belial - Starts with it and 3 coins

How to Unlock:
Kill Mom's Heart 10 Times!

Unlocks:
The Poop - Starts with it

How to Unlock:
Complete 2 floors with picking up hearts

Unlocks:
♥♥♥♥♥ of Babylon - Starts with it
Dead Bird - Starts with it
Razor Blade - Donate 439 coins to the Greed Donation Machine after killing Ultra Greed A

How to Unlock:
Complete 2 floors with getting hit.

Unlocks:
Bloody Lust - Starts with it
Child's Heart - Complete Ultra Hard Challenge A+

How to Unlock:
Make 3 devil deals in one run

Unlocks:
The Fool - Starts with it
Brimstone (Azazel Version) - Unobtainable unless Azazel.

Side Effects:
Can Fly

How to Unlock:
Get 4 Soul (blue) Hearts in one run

Unlocks:
Blue-Blue Pill - Starts with it
Anemic - Complete Back@$$wards

How to unlock a Token:
Kill Mom's Heart, It lives, Ultra Greed A, The Beast R

Unlocks:
Random each time

Side Affects:
Appearance will change each time

How to Unlock:
Die holding the proof of terror

Unlocks:
Holy Mantle - Donate 879 coins to the Greed Donation machine A
D4 - Unobtainable in Repentance, Blow up 30 Slot Machines. A

How to unlock:
Complete Greed Mode with Azazel A

Unlocks:
Box of Friends - Starts with it
Incubus - Starts with it
Cambion Conception - Starts with it

Side Effects:
Blindfolded, she can't shoot her own tears.

How to Unlock
Donate 1000 coins to the Greed Donation Machine A

Unlocks:
Wooden Nickel - Kill Isaac as the secret character
1 coin - Kill Hush
Store Key - Kill Satan

Side Effects:
Greed consumed him
The devil thanks you
Kill the hushed to be stronger

How to unlock:
Kill the final boss for the first time

Unlocks:
Void - Starts with it

How to unlock:
Receive the parts of her shovel, then dig up the dead child in a secret dark room room. A

Unlocks:
None

Side effects:
Melee
Split his soul and body

How to Unlock:
Kill Mom's Heart on Hard Mode

Unlocks:
Book of Virtues - Starts with it

How to Unlock:
Kill Mother for the first time

Unlocks:
None

Go away, the guides over.