Life Story IV

After meeting Gionne in person, they followed her to the Monarch Room, and were ambushed by the cloaked woman before Wesker made his appearance. Redfield demanded to know Valentine's whereabouts and was stunned when Wesker revealed that the cloaked woman was none other than a brainwashed Valentine. Redfield and Alomar were overwhelmed by Valentine and Wesker's combined force. However, as Wesker prepared to leave, Redfield broke through to Valentine and caused her to struggle against her programming, making Wesker increase Valentine's pain, turning her primal, inadvertently revealing the mind control device on her chest, which Redfield managed to forcefully remove. While Valentine became dizzy and faint, Redfield was relieved that she was alive and back to her senses. Valentine urged Redfield to stop Wesker before he could finish his preparations, and despite his initial refusal out of concern for her safety, he reluctantly left her to give chase.

Redfield and Alomar pursued Wesker and Gionne aboard a large tanker, fighting their way across the deck of the ship and reaching the inside where they encountered Gionne once again. As they attempt to question her, she flees in a panic, escaping the room and dropping a briefcase containing several injectors of PG67A/W. While not knowing its use, Redfield deduced its importance and kept it. He eventually caught up with Gionne, now limping and writhing in agony after Wesker infected her with Uroboros. Upon her mutation into Uroboros Aheri, Redfield and Alomar retreated to the bridge, where they eventually defeated her with a Satellite Laser Device before setting their sights on Wesker.

Shortly before the encounter, Redfield received a call from Valentine, who explained that Wesker needed to inject himself with a serum - the same one he recovered from Gionne - to keep the virus inside of him stable and that an overdose would poison him. After a tough brawl with Wesker, Redfield and Alomar managed to outsmart him and inject the serum into his chest, causing him great pain and forcing a retreat to a stealth bomber, which Redfield and Alomar only barely board in time. The fight continued in the cargo bay before Redfield managed another injection in Wesker's neck, labeling him as "just another one of Umbrella's leftovers." Taking advantage of Wesker's weakness, Redfield opened the cargo door and sent him flying across the room, only for Wesker to desperately cling to Alomar's leg, and as Redfield watched, images of Valentine rushed through his mind as he remembered how he thought he had lost her trying to kill Wesker. Before Alomar could sacrifice herself by letting go, Redfield managed to grab her, allowing her to shoot Wesker and send him shooting out of the plane.

Crashing into a volcano, Redfield and Alomar emerge from the wreckage and witness an enraged Wesker puncturing a container of Uroboros to mutate himself. Forced to retreat, the pair became separated when the ground gave way under Redfield. Redfield did his best to fight Wesker on his own, but soon Wesker diverted his attention to a stranded Alomar, forcing Redfield to use a huge boulder to bridge the gap between them and regroup. The pair then made their final stand against Wesker and stunned him long enough to have the ground beneath him give way, causing him to fall straight into the lava as Valentine and Josh arrived overhead in a helicopter. While the pair board the chopper, Wesker makes a last ditch effort and stretches his arm to grab the helicopter, but Redfield and Alomar use the onboard RPGs to obliterate Wesker permanently.

In the aftermath, Redfield finally realized what he had been fighting for, and although he felt he had accomplished all that he had set out to do, he knew that it was only a matter of time before someone like Wesker showed up again. For this reason, Redfield decided to go back to working in a team, passing on his knowledge and skills to a new generation for when that day finally came. After the events in Kijuju, Redfield took Valentine back to the United States for rehab and recovery from Wesker's experiments. Shortly after, he received an e-mail from Burton, expressing his relief that they had returned and offering to meet to catch up after they recover from the ordeal in Africa. Posteriorly, Redfield and Valentine asked Burton to join BSAA, which he eventually accepts.